Imaging can only assess the high risk of malignancy of ground-glass nodules characterized by lobularity, burr-like shape, internal vacuoles, and rich blood supply, and it is difficult to determine the severity. The risk of malignancy is assessed on the basis of the morphology, size, margins and other characteristics of the nodule. In most cases, it is difficult to determine the benign or malignant nature of the nodule and the degree of malignancy, e.g., some nodules with malignant signs are confirmed to be benign after histologic examination. The severity mostly needs to be confirmed by pathologic examination. In general, the malignant possibility of ground glass nodules is higher in those with lobulated morphology, presence of burrs and spines, size ≥2cm, vacuoles within the nodule, rich blood supply of the nodule, peripheral vascular aggregation, etc., as well as mixed ground glass nodules with a high proportion of solid components, which should be closely followed up or biopsied or operated on. Patients are advised to consult a specialist and choose the appropriate treatment plan according to their own situation, lesion condition and personal wishes.