Liver stones belong to benign lesions, which usually do not affect the patient’s life, but may affect life if serious infection occurs and bile duct malignant tumor is induced. 1. Serious infection: when intrahepatic bile duct stones develop serious infection, leading to acute purulent obstructive cholangitis, it may induce infectious shock and other conditions, which may lead to the death of the patient, at this time, we should pay attention to the early detection of the severity of the infection, and the early application of antibiotics to treat it. 2. Inducing malignant tumor of bile duct: If intrahepatic bile duct stones are not treated for a long time, it may induce malignant tumor of bile duct. Early stage cholangiocarcinoma can be operated positively, and the survival rate can reach 70% in 5 years, while the survival rate of middle and late stage cholangiocarcinoma patients in 5 years is about 5%. For patients with intrahepatic bile duct stones, it is recommended to follow up closely and consult the Department of Hepatobiliary Surgery of regular hospitals.