Osteoporosis caused by Letrozole needs to stop taking the drug in time, supplement calcium and vitamin D, and exercise properly. 1. Discontinue the drug: Letrozole will lead to a decrease in the level of estrogen, estrogen has the effect of preventing bone calcium loss, long-term use of Letrozole will lead to osteoporosis, if the diagnosis of osteoporosis, you should reduce the dosage or stop the drug. 2. Supplementation of calcium and vitamin D: After osteoporosis, it is recommended to supplement calcium and vitamin D, such as consuming calcium tablets, calcium gluconate, and increasing ultraviolet irradiation to promote calcium absorption. 3. Appropriate exercise: During the process of anti-osteoporosis treatment, you can exercise appropriately to strengthen the bone and muscle strength, protect the bone and help promote the normal growth of bone, but should pay attention to the intensity of exercise to avoid excessive exercise resulting in pathologic fracture. It is recommended to consult a doctor in a timely manner, depending on the doctor’s advice to carry out the appropriate treatment, the above drugs need to be used under the guidance of a physician.