The wrinkles on the hands may be caused by physiological factors such as too long a time in the water, too low water temperature, or hereditary palmoplantar keratosis, progressive finger-palm keratoderma and other diseases. 1. Physiological factors: if the hands are wet for a long time, the skin surface of the stratum corneum in the repeated absorption of water, the surface will be swollen, white, while the bottom of the dermis layer did not change, this time the epidermal stratum corneum and the dermis layer stacked on top of each other, it will make the skin wrinkles. In addition, the hands touch cold water, local blood vessels and nerves will appear contraction, will also lead to skin wrinkling symptoms. 2. Hereditary palmoplantar keratosis: The cause of hereditary palmoplantar keratosis is still unclear, and it is considered to be related to autosomal dominant inheritance or autosomal invisible inheritance. Patients may have yellowish hard keratotic plaques on the palmoplantar areas, and some patients may have symptoms such as cracking, itching, and tenderness. If the patient’s lesions are exposed to water for a long time, it will lead to localized swelling of the stratum corneum, and the skin may become wrinkled. 3. Progressive angular dermatosis of the fingers and palms: progressive angular dermatosis of the fingers and palms is due to long-term exposure to chemical solvents, endocrine function abnormalities, etc., the patient will appear localized skin dryness, cracking, flaking, thickening of the stratum corneum and other symptoms. If the patient’s hands are exposed to water, it will lead to softening and swelling of the stratum corneum in the affected area to absorb water, which will lead to the symptoms of skin folds. It is recommended that the wrinkled skin on the hands after exposure to water requires prompt medical attention, and if it is caused by physiological factors, no treatment is needed. If it is caused by disease, you need to choose the appropriate measures under the guidance of the doctor to treat.