Big toe joint pain when pressed may be caused by onychomycosis, bunion, gouty arthritis and so on. 1. Inflammation of the nail: it is an inflammation of the tissues around the toenail, mostly caused by various pathogenic bacterial infections, manifesting as redness, swelling, heat and pain in the local tissues, and in the more serious cases, it may turn into pus. The big toe is the most easily squeezed of the toes and is prone to gingivitis, which can cause pain. 2. Bunion: It is a bunion that turns outward, mostly caused by congenital flat feet or wearing inappropriate shoes after birth. When the front of the foot is subjected to prolonged stress, the toes will be gradually deformed, which will cause pain. 3. Gouty arthritis: It is an inflammatory reaction caused by the deposition of urate in the joint capsule, cartilage or other tissues, which manifests itself as swelling, warmth, redness and pressure pain in the tissues around the joints. The toes are the most common site of gouty arthritis, and the joints can become painful when pressed. There may be other reasons for the pain when the big toe joint is pressed, such as bunions caused by ill-fitting shoes. It is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy.