Irbesartan and Irbesartan hydrochlorothiazide can not be compared, need to be evaluated according to the condition of the selection of appropriate drug treatment is better. Clinically, Irbesartan belongs to the angiotensin II receptor antagonist, which is mainly used for the treatment of essential hypertension, hypertension combined with type 2 diabetic nephropathy. Dizziness, hypotension, skeletal muscle pain, tinnitus and other discomforts may occur after the use of this drug. The drug is contraindicated in people who are allergic to the components of the drug, pregnant women in the 4th to 9th month of pregnancy, breastfeeding women. Liver and kidney functions, blood pressure need to be monitored during the course of medication, while children, the elderly and other special groups, need to use the drug under medical supervision. Irbesartan Hydrochlorothiazide Tablets belongs to the compound preparation, with the addition of hydrochlorothiazide as a diuretic, which is able to reduce the extracellular volume, lower the vascular resistance as well as inhibit vasoconstriction after taking the drug, and is mainly used in the treatment of hypertension in which Irbesartan or Hydrochlorothiazide alone fails to effectively control the blood pressure. The drug may cause dizziness, headache, nausea, vomiting and other discomforts after taking it. It is contraindicated in people who are allergic to the components of the drug, people with severe hepatic and renal impairment, pregnant women in the 4th to 9th month of pregnancy, people with hypersensitivity to sulfonamide derivatives, people with intractable hypokalemia, hypercalcemia, biliary cirrhosis and cholestasis. Blood pressure, liver and kidney function should be monitored during the course of medication, and special groups such as the elderly and children should use the medication under the guidance of a doctor. All of the above medications should be used under the guidance of a doctor, avoid self-medication to avoid adverse consequences.