Hepatitis B virus replicates in quantities of DNA greater than 1,000, and antiviral drugs are usually needed for treatment. The need for antiviral therapy is assessed clinically by taking into account the patient’s clinical symptoms, aminotransferase levels, liver ultrasound findings, and the number of replicating hepatitis B viruses. Patients with elevated aminotransferase levels greater than twice the normal high and hepatitis B virus replication counts greater than three times 10 require antiviral therapy. Hepatitis B viral load is usually only an indicator of viral replication, so it needs to be combined with the patient’s liver function and the presence of liver fibrosis or cirrhosis. The presence of immune tolerance, hepatitis B virus replication number increased, can also be considered not to use the drug first. Consult the Department of Infectious Diseases of a regular hospital if you find that the number of hepatitis B virus replicates is high. Diagnosis and treatment should be carried out under the guidance of specialized doctors.