The big blisters after cryotherapy are mainly the inflammatory reaction of the tissues after low temperature, which can be absorbed by themselves under normal circumstances, while some of the blisters need to be drained by puncture to promote their absorption. The large blisters that appear after cryotherapy can generally be gradually absorbed by the body, during this period is mainly to pay attention to keep the local skin clean, avoid excessive friction and stimulation, so as not to cause the blisters to rupture and induce infection. For larger blisters or blisters with signs of concurrent infection, it is important to seek medical attention in a timely manner, and the doctor will use a sterile needle to puncture and drain the fluid in the lower part of the blister. After the puncture is completed, it is important to enhance skin care and avoid getting wet to avoid infection. Due to the different physique of individuals, the absorption time of blisters may vary greatly. For specific cases, it is necessary to ask for a doctor’s interview and choose the treatment in the light of the actual situation.