Anti-sperm antibodies have a greater impact on conception, but due to individual differences, the specific chances cannot be clarified. If a man produces anti-sperm antibodies, it is easy to cause sperm agglutination, localized swelling, and then the sperm’s ability to penetrate the cervical canal is reduced or can not penetrate into the uterine cavity that is dead, not only affects the quality of sperm, but also prevents the sperm from meeting with the egg, so it will reduce the chances of women’s fertilization. If a woman produces anti-sperm antibodies, the male sperm will enter the body and cause the autoimmune system to react, engulfing the sperm or preventing the fertilized egg from combining with the sperm or preventing the fertilized egg from implanting in the uterine cavity, thus lowering the chances of a woman’s conception. For women who are actively preparing for pregnancy but still cannot get pregnant, it is recommended that they complete ultrasound, sex hormone, blood routine, biochemistry, immunity and other related examinations, except for immune diseases, ovarian dysfunction and other related illnesses, and under the guidance of the doctor, actively treat the disease in order to increase the chances of pregnancy.