Traditional Chinese medicine believes that heat in the hands and feet is mostly related to yin deficiency and fire, and can be treated with drugs that can nourish yin and clear heat, such as Zhi Bai Di Huang Wan (知柏地黄丸). Zhi Bai Di Huang Wan consists of Zhi Mu, Shu Di Huang, Huang Bai, Cornus officinalis (system), Chinese yam, Mudan Pi, Poria, etc. It has the effect of nourishing yin and lowering fire, and it can be used for the treatment of yin deficiency and fire, hot flashes and night sweating (sweating abnormally after falling asleep, but sweating stops after waking up), dry mouth and throat, tinnitus, spermatorrhea, and urination (urination is small in quantity and dark yellow in color). It should be noted that the drug should not be taken at the same time with cold and flu medicines. For patients with fever in the hands and feet, it is recommended to go to regular hospitals for correction and treatment under the guidance of professional physicians for evidence-based treatment.