Infected with Helicobacter pylori, ate fourteen days of quadruple therapy, hungry and some discomfort is considered to be an adverse reaction to the drug, gastric mucosal damage caused by the acid-suppressing drugs such as omeprazole can be given, and some patients can be relieved after stopping the drug. Helicobacter pylori positive people are generally given 4 combination therapy, the stomach after 14 days of medication there are some discomfort symptoms, mainly because the eradication of Helicobacter pylori kills Helicobacter pylori, although 14 days of medication can kill the bacteria, but for the gastric mucosa can not be completely repaired. Therefore, when there is a feeling of hunger, nausea, stomach pain, epigastric fullness and discomfort and other symptoms are serious, it is necessary to continue to give 2 to 4 weeks of acid-suppressing drugs, such as rabeprazole, omeprazole and so on, after stopping antibiotics. The duration of medication may be longer when acid reflux symptoms are pronounced. Symptoms that are uncomfortable for a portion of patients after 14 days of medication may resolve on their own after discontinuing the medication. After H. pylori infection, it is recommended to adhere to the doctor’s instructions, standardized use of drugs, not self-medication.