48-year-old woman legs swollen, eyelids also swollen more, caused by kidney disease, cardiovascular disease, liver disease, anemia and so on. 1. Kidney disease: patients with kidney disease may have lower limb and eyelid edema, such as patients with nephrotic syndrome, due to a large amount of proteinuria, hypoproteinemia may occur, resulting in generalized edema, obvious eyelid, and double lower limb edema. 2. Cardiovascular disease: when patients suffer from heart failure, it may lead to pulmonary circulation stasis and body circulation stasis, resulting in water and sodium retention in the body, which in turn leads to lower limb edema and eyelid edema. 3. Liver disease: chronic hepatitis, etc., may lead to cirrhosis. Liver dysfunction may reduce protein production, and the patient may develop ascites and eyelid and lower limb edema. It is recommended that patients with swollen legs and swollen eyelids also seek timely medical attention to assess their condition and follow the doctor’s instructions for treatment.