There are many side effects of taking sodium bicarbonate for a long period of time, some of the common ones are indigestion, hypernatremia, renal impairment, and metabolic alkalosis. Sodium bicarbonate is an alkaline substance, so it has an antacid effect and is usually used in the treatment of stomach pain, heartburn and heartburn sensation caused by excessive stomach acid. If taken for a long period of time, it will have a neutralizing effect on stomach acid, affecting the digestion and absorption of food and causing symptoms of indigestion such as loss of appetite, nausea, and epigastric fullness. The sodium ions contained in it will lead to hypernatremia, increase the burden of sodium excretion by the human kidneys, and even cause damage to renal function, as well as lead to metabolic alkalosis. In addition, long-term use may also lead to symptoms such as frequent urination, urinary urgency, persistent headaches, and unusual fatigue and weakness. It is not recommended for children under six years of age, appendicitis or similar symptoms without a confirmed diagnosis, as well as the presence of symptoms of gastrointestinal bleeding. This drug should be applied under medical supervision and should not be taken for a long period of time. In case of adverse reactions, it is recommended to go to the hospital as soon as possible and take relevant measures under the supervision of a doctor.