Thin lining after down regulation is not related to high estradiol.
Down-regulation also means releasing the control of the hypothalamus and pituitary gland over the ovaries, so that the ovaries can develop multiple follicles, which is helpful in treating infertility and IVF to a certain extent.
Of course, for IVF, successful egg retrieval is only the first step, it is more important that the woman’s uterine environment is stable and healthy, and if the uterine lining is thin, it may lead to embryo transfer failure.
And the endometrium is regulated by estrogen and progesterone. Generally speaking, estrogen promotes the growth of the endometrium, and then during menstruation, because of the sudden drop in estrogen and progesterone levels, the endometrium will be shed and menstruation will occur.
Therefore, high estradiol does not cause a thin endometrium. If the endometrial lining is found to be thin after lowering the regulation, further examination should be conducted to identify the cause of the problem and target treatment.
It is important to note that IVF needs to be done in a regular medical institution and not in an illegal one.