Menstruation usually occurs after 6 injections of leuprolide. Menopause often occurs during leuprolide injections, and menstruation usually resumes within a few months after discontinuation. Leuprolide is a synthetic gonadotropin-releasing hormone agonist commonly used in gynecology, which can inhibit the action of the pituitary gland on the ovaries, resulting in temporary amenorrhea, and is used in the treatment of endometriosis and uterine fibroids. Leuprolide, due to the decrease in ovarian function and hormone levels, will cause amenorrhea during the medication period, which will alleviate the symptoms of dysmenorrhea, as well as some abnormal symptoms such as hot flashes and osteoporosis due to low hormone levels. After stopping the drug, ovarian function can be restored, ovulation and menstruation can occur, and hot flashes can improve, but the recovery of osteoporosis symptoms will take longer. Patients who need to use leuprolide need to use it under the supervision of a doctor, and if uncomfortable symptoms occur, estrogen levels can be raised appropriately under the supervision of a doctor.