Men who have been ligated for more than 30 years may experience the side effects of epididymal sludge and sperm granuloma. Men who have been ligated for 30 years may experience the side effect of epididymal sludge, but this side effect most often occurs 6 months after the ligation procedure, and fewer people experience epididymal sludge after 30 years of ligation. In addition, sperm granuloma can occur. The occurrence of sperm granuloma may lead to the development of a localized mass accompanied by pain and swelling. After the occurrence of sperm granuloma, the organism may initiate natural recanalization, leading to failure of sterilization, or sperm granuloma may block the epididymal ducts, leading to permanent sterilization, and it may cause the organism to develop an autoimmunity to spermatozoa. Men who have been sterilized for more than 30 years usually don’t experience any other side effects such as bleeding, infections, or painful vas deferens nodules. If symptoms of discomfort at the site of the ligation or in the scrotum occur after 30 years of ligation, it is advisable to seek medical attention to identify the cause and have it addressed by a doctor.