Taking diclofenac sodium for ankylosing spondylitis is usually effective. Diclofenac sodium is an anti-inflammatory and analgesic drug, mainly used for the treatment of acute and chronic arthritis, rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, spinal arthropathy and other joints, spinal swelling and pain. Ankylosing spondylitis belongs to a kind of chronic joint inflammation, which is mainly characterized by low back pain, spinal ankylosis, knee, hip and ankle joint pain. The pain worsens early in the morning or after sitting for a long time, and decreases after activities, and some patients will be accompanied by weakness, cough, incontinence and other symptoms. Mainly through the use of drug therapy, advanced spine, hip and knee joint ankylosis or severe deformity can be surgical treatment. 1. Non-steroidal anti-inflammatory drugs: they have good pain-relieving effect on joint pain caused by ankylosing spondylitis, and the common drugs are diclofenac sodium, celecoxib, naproxen and so on. Long-term use of gastrointestinal adverse reactions, such as nausea, vomiting, diarrhea and so on. 2. Anti-tumor necrosis factor α antagonist: can control the condition, common drugs are enasip, infliximab, adalimumab, etc., need to take long-term effect is obvious. 3. Anti-rheumatic drugs: mainly for young patients with mild peripheral arthropathy, commonly used drugs are Liuzasulfapyridine, methotrexate and so on. Late spine, hip and knee joints with severe deformity can use total hip arthroplasty, spinal osteotomy and other surgical treatments. All of the above drugs should be used under the guidance of a doctor. It is recommended that patients with ankylosing spondylitis go to the hospital in time and follow the doctor’s instructions for standardized treatment.