Esophageal biopsy can cause bleeding due to mucosal injury, which is normal if the bleeding is small and not considered normal if it is large. 1. Normal phenomenon: The esophageal biopsy itself is to take a piece of tissue from the mucosa of the esophagus for pathological examination, due to the friction of the endoscope on the esophagus or the injury to the small blood vessels when taking the biopsy will cause a small amount of bleeding, which is considered to be a normal phenomenon, and generally can stop bleeding without special treatment. 2. Abnormal phenomenon: If there is a large amount of bleeding during esophageal biopsy, it is usually due to perforation of the esophageal mucosa, esophageal tumor cleavage, or severe damage of the esophageal mucosa, which are not normal phenomena, and active symptomatic treatment is needed to effectively stop bleeding. In conclusion, if there is a large amount of bleeding during esophageal biopsy, it is recommended to take appropriate treatment measures under the guidance of a doctor as soon as possible.