The malformation rate of second generation IVF babies is relatively low and will not be higher than the malformation rate of normally conceived babies. The second generation of IVF is an IVF technique for men with severe oligospermia, weak spermatozoa, and abnormal spermatozoa. Doctors will screen the male sperm, and force the sperm to the egg under the microscope to make it combine, and this process is a screening process for the sperm, so that the chances of the fetus having deformities will be lower. The malformation rate of second generation IVF is mainly determined by its own chromosomes, and choosing high-quality egg cells and sperm to combine before doing IVF can reduce the malformation rate of IVF. After the successful conception of second generation IVF, it is necessary to do a good job of maternity examination during pregnancy, such as NT examination, Down’s syndrome, 4D ultrasound, amniocentesis, etc., in order to know whether there is any abnormality of the fetus development in the uterus.