Hepatitis B surface antigen cleared is good, if the later review did not re-positive, that is completely well. Clinically, there are a small number of patients through effective antiviral treatment, can achieve surface antigen turn negative or clear. This indicates that the condition has been improved. In addition, there are a small number of patients because of their own immunity, in the process of hepatitis B virus infection gradually recovered on their own, may also achieve hepatitis B surface antigen negative. This indicates that the condition is recovering. If the surface antigen of hepatitis B becomes negative, the number of hepatitis B virus can not be measured, and if there is also the production of surface antibodies, this indicates that the body has produced protective antibodies, which basically indicates that the treatment has been successful or self-cured. It is recommended that patients with hepatitis B should have regular consultation in hepatology or infectious diseases department.