Sodium bicarbonate injection is used to gargle and can be an aid in treating fungal infections of the mouth. Sodium bicarbonate injection can create an alkaline environment in the mouth, and fungus is not suitable for alkaline environment, so although sodium bicarbonate injection can not be anti-fungal, but can effectively inhibit the growth of fungus. Patients with fungal infections such as mouth sores and denture stomatitis can use sodium bicarbonate injection to gargle to inhibit fungal growth. Common adverse effects of sodium bicarbonate injection when administered intravenously include cardiac arrhythmia, pain, muscle spasm, and slowed respiration, etc. Topical gargling is generally not associated with significant adverse effects, and contraindications are unclear. In addition, the use of sodium bicarbonate injection carries a certain degree of risk, and patients need to be guided by a specialist.