Injuries generally do not cause vitiligo. The causes of vitiligo include genetic factors, autoimmunity, oxidative stress, the theory of melanocyte self-destruction, and the theory of neurochemical factors.
1. genetic factors: vitiligo is mainly refers to the acquired pigmentation loss of skin mucosal diseases, injuries generally do not lead to vitiligo. The patient can appear family gathering phenomenon, belongs to the category of polygenic diseases, can be in the genetic and environmental factors under the joint action of the onset.
2. autoimmune: due to the patient’s body can exist anti-melanocyte antigen autoantibodies, or the patient himself suffers from some autoimmune disease will make the occurrence of profile increase. Some patients oral glucocorticoid effect can also prove the occurrence of vitiligo may be related to autoimmunity.
3. oxidative stress: the existence of redox imbalance in the lesion area, the reduction of antioxidant enzyme levels, affecting melanocyte metabolism, proliferation and differentiation.
4. Melanocyte self-destruction theory: epidermal melanocyte hyperfunction and accelerated depletion.
5. Neurochemical factor theory: may be related to neuropsychiatric factors, certain substances increase so that melanin synthesis is impeded.
Vitiligo is usually not caused by injury, mainly due to the above factors, the appearance of white spots should be timely consultation, under the guidance of the doctor for treatment, pay attention to rest, avoid exertion.