Blisters on the skin of the mouth should be treated according to the cause of the disease, the general cause of allergies, labial inflammation, herpes simplex, etc., you can improve the symptoms through general treatment, medication and so on. 1. Allergy: If the lips are exposed to certain substances caused by an allergic reaction, the general treatment includes immediate detachment from the allergen, oral loratadine, cetirizine and other drugs as prescribed by the doctor, or topical boric acid solution wet compresses, and so on. 2. Lipitis: blisters caused by lipitis, can follow the doctor’s instructions for local topical isacridine solution, boric acid solution and other drugs, there is an infection can be used externally fusidic acid cream and so on. 3. Herpes simplex: If herpes simplex is caused by the need to avoid scratching, light diet, regular work and rest, can follow the doctor’s instructions oral acyclovir, vasiclovir and other medications, at the same time can be used topically acyclovir ointment, penciclovir ointment, etc., secondary infections can be used under the guidance of the doctor fusidic acid ointment, mupirocin ointment and other topical. All of the above drugs should be used under the guidance of a doctor, do not use drugs without authorization.