For patients with duodenal descending tumor metastatic liver cancer, the tumor is already in the advanced stage, try to prolong the survival period through treatment, at present, for this kind of patients, it is necessary to carry out the comprehensive consultation of relevant departments, improve the relevant examination, and carry out individualized treatment. For patients who can tolerate surgery, after relevant conservative treatments, the physical condition of the patients can be improved and they can tolerate surgery, and they can undergo radical resection, but it cannot achieve the clinical effect of complete cure. For patients who cannot tolerate surgery, radiofrequency ablation can be performed to delay the deterioration of the disease. Liver cancer is less sensitive to radiotherapy, so it is necessary to decide whether to carry out radiotherapy or chemotherapy according to the patient’s response to radiotherapy. Patients with liver metastasis should adjust their dietary structure and supplement nutrition. The treatment plan for patients with duodenal descending tumor metastasis of liver cancer should be based on the actual situation, and the patients need to actively cooperate with the doctor for treatment, and actively treat under the doctor’s guidance.