Blisters on the penis are considered to be genital herpes simplex. Genital herpes simplex is caused by the herpes simplex virus infection, the main symptoms of men’s penis skin, foreskin, glans, coronal groove and urethral orifice, one or more small blisters, blisters can rupture oozing, pain, as well as burning, itching sensation. Genital herpes simplex, in addition to causing small blisters on the penis, may also be accompanied by fever, headache, muscle aches and other flu-like symptoms. The penile urethral orifice may also have pus discharge, and there may be pain when urinating. There is no cure for genital herpes simplex, but medications can be used to relieve the pain and itching. Commonly used medications include antiviral drugs such as acyclovir and valacyclovir, and analgesics such as ibuprofen and acetaminophen. Please use medication under the guidance of your doctor after a clear diagnosis.