More gastric fluid in empty stomach may be a disease state caused by chronic gastritis, gastric ulcer, gastrinoma. 1. Chronic gastritis and gastric ulcer are mainly caused by Helicobacter pylori, which can stimulate the proliferation of gastric mucosal cells on the stomach wall, leading to an increase in the secretion of gastric acid and thus causing chronic gastritis. The persistence of gastritis can cause gastric ulcers. It is often manifested as epigastric discomfort, nausea, loss of appetite and so on. 2. Gastrinoma is a kind of enteropancreatic endocrine tumor, which is small in size, multicenter and ectopic. Its main manifestations are hypergastrinemia and high gastric acid secretion. Clinical symptoms are abdominal pain, diarrhea and other conditions. If the above situation occurs, please consult a doctor in time for reasonable and standardized diagnosis and treatment.