Psoriasis is a chronic scaly skin disease caused by the interaction of many factors, commonly used oral anti-itch medications such as antihistamines and immunosuppressants. 1. Antihistamines: such as cetirizine hydrochloride tablets, loratadine tablets, ibastine tablets, etc., which have a better effect on itching after oral intake. 2. Immunosuppressants: such as methotrexate, cyclosporine and other immunosuppressants can be used in psoriasis to relieve itching. In addition to oral medication, psoriasis can also apply topical medication to stop itching, such as glucocorticoid ointment (hydrocortisone butyrate cream), lincomycin lidocaine gel, etc. Applying the medication to the affected area can also achieve the purpose of stopping itching. Psoriasis should be treated promptly and professionally to prevent exacerbation or recurrence of the disease. Medications should be used as prescribed by the doctor.