The treatment of bitter mouth should first find out the cause of the disease, such as gastrointestinal diseases can be used omeprazole, as well as liver diseases can be used hydromorphone, mouth ulcers use ice borax, etc.. The most common gastrointestinal disease that leads to a bitter mouth is gastroesophageal reflux disease (GERD), because GERD will reflux stomach contents into the esophagus or even into the mouth, which can lead to a bitter mouth, and the main medications used include acid-suppressing medications, such as omeprazole, or gastric stimulating medications, such as mosapride, and so on. Liver disease can also lead to a bitter mouth, in addition to indigestion, discomfort in the liver area, etc. In mild cases, the main focus is on the protection of liver function, and can be used with medications such as silymarin and reduced glutathione. Mouth ulcers are also common diseases that cause bitter mouth, in addition to localized pain in the mouth, bad breath, etc. The main use of topical drugs, such as ice boron powder, potassium permanganate solution, etc.. For the treatment of the above diseases, it is important to consult a doctor in time, and use medication under the doctor’s guidance after a professional examination, and not to use medication privately.