Liver perforation, usually associated with liver cysts, hepatic hemangioma, intrahepatic cholangiocellular adenoma and other diseases. 1. Liver cysts: relatively small cysts are not easy to occur liver perforation, if larger liver cysts are not treated in time, they may rupture and bleed on their own, resulting in the so-called liver perforation. 2. Hepatic hemangioma: if the hemangioma is obviously enlarged and subjected to external force, it may cause rupture of the liver, which is known as liver perforation and is accompanied by pain in the liver area. 3. Intrahepatic cholangiocellular adenoma: small intrahepatic cholangiocellular adenomas usually do not cause liver perforation; if the tumor is large, it is easy to cause liver perforation after invading into liver tissues. In addition to the above diseases, liver perforation should also be considered to be caused by hepatic cysticercosis and liver cancer, etc. It is recommended to check the cause of liver perforation as soon as possible and carry out treatment after clarifying the cause of the disease.