Hypoechoic mass in the right posterior lobe of the liver is an abnormal manifestation of liver ultrasonography, which is considered to be related to hepatic hemangioma, intrahepatic calcified foci, intrahepatic bile duct stones, hepatocellular carcinoma and other diseases. 1. Hepatic hemangioma: The first consideration for a hyperechoic mass in the right posterior lobe of the liver is hepatic hemangioma. Hepatic hemangioma is a large number of arteriovenous vascular malformations in the liver, which can be manifested as a well-defined hypoechoic occupancy with posterior hypoechoic enhancement on ultrasonography. 2. Intrahepatic calcified foci: Intrahepatic calcified foci are often formed by intrahepatic bile duct stones, intrahepatic chronic inflammation or trauma, parasitic infections, benign and malignant tumors of the liver and intrahepatic metastatic tumors with calcification, and congenital developmental formation, etc. They can be presented as hyperechoic structures with clear boundaries and posterior hyperechoic enhancement during ultrasound examination. It can be seen as a hyperechoic mass during ultrasound examination. 3. Intrahepatic bile duct stones: Intrahepatic bile duct stones are often caused by bacterial infection, parasitic infection and bile retention. They may appear as a hypoechoic mass on ultrasound, followed by acoustic shadowing. Intrahepatic bile duct stones are usually accompanied by epigastric pain, long history of biliary tract disease and other clinical symptoms. 4. Hepatocellular carcinoma: It is relatively rare to see hyperechoic mass in ultrasonography, if the hyperechoic mass is accompanied by irregular morphology, unclear boundary, obvious abnormal blood flow signal, etc., it is necessary to exclude hepatocellular carcinoma in time. If hyperechoic mass is found in the right posterior lobe of the liver, it is necessary to go to the hospital in time for examination, clarification of the specific cause and treatment, so as to avoid delaying the condition.