The cause of multiple system atrophy has not yet been clarified, and there is no new treatment method. The treatment of multiple system atrophy mainly focuses on the symptomatic treatment of postural hypotension and Parkinson’s-like symptoms caused by the disease, as well as the treatment of other secondary symptoms. 1. Treatment for postural hypotension: multiple system atrophy will cause autonomic dysfunction and lead to postural hypotension, which can be treated by wearing compression stockings, taking α-agonist midodrine, hydrocortisone, ephedrine and other drugs. 2. Parkinson’s-like symptoms: multiple system atrophy damaging nigrostriatal dopamine neurons will cause Parkinson’s disease, patients can take levodopa, pramipexole and other drugs for symptomatic treatment. 3. Treatment of the remaining secondary symptoms: multiple system atrophy can also cause spasm of the urethral muscle, dystonia symptoms, patients can take trazodone, tolterodine symptomatic treatment. Multi-systemic atrophy is a rare disease, and there is a lack of specific treatment, so it is recommended that patients receive symptomatic treatment under the guidance of a doctor in order to prolong the survival period.