The proper way to eliminate closed skin acne includes general treatment, topical medication, oral medication, physical therapy, and more. Closed-cell acne, or whitehead acne, is a chronic skin disease that occurs in the sebaceous glands of hair follicles. 1. General treatment: First of all, pay attention to skin hygiene and cleanliness, pay attention to the use of mild cleanser to wash the skin, reduce the skin cosmetics, keratin and other material residues, ensure that sleep, pay more attention to rest. 2. Topical medication: for the milder symptoms of closed mouth acne, can be used externally retinoic acid drugs, such as retinoic acid ointment, isotretinoin, etc.; inflammation is more pronounced, can be combined with topical antibiotic treatment, such as mupirocin ointment, erythromycin ointment, etc.; but also can be used externally azelaic acid cream, to reduce the production of hyperpigmentation. 3. Oral drug treatment: for the inflammation is heavy, the effect of external drug treatment is not good, oral antibiotic treatment, such as doxycycline, minocycline, etc.; for the eruption of closed mouth acne, oral glucocorticoid treatment, such as prednisone. 4. Physical therapy: Combined with outbreaks of acne can take photodynamic, red and blue light, laser and other physical therapy, closed mouth acne can also be used to remove fruit acid peel. It is recommended that patients avoid squeezing closed-cell pimples with their hands to avoid secondary infections. When using medication, it is important to follow the doctor’s instructions strictly, not blindly self-medication.