Hepatitis B patients with secondary hepatitis suggests that hepatitis B virus replication is more active, and should be actively treated with antiviral therapy and hepatoprotective therapy. Corresponding treatments should be taken according to the stage of the disease, including general treatment, hepatoprotective therapy, antiviral therapy and so on. 1. General treatment: take proper rest and avoid overwork; eat a light diet that is easy to digest and rich in vitamins. If there is loss of appetite, nausea and vomiting, intravenous energy should be supplied; alcohol consumption is prohibited. 2. Hepatoprotective treatment: appropriate choice of hepatoprotective drugs for treatment, such as reduced glutathione, glycyrrhizic acid preparation, bicyclic alcohol and other anti-inflammatory, reduce peroxide damage and other drugs. For patients with intrahepatic cholestasis, ursodeoxycholic acid and adenosylmethionine can be used for bilirubin treatment. 3. Antiviral therapy: nucleoside analogs such as tenofovir, entecavir and interferon can be used for antiviral therapy. Hepatitis B patients with secondary hepatitis should be alert to viral amplification and mutation, and take active treatment according to the changes in liver function and hepatitis B five.