The after-effects of long-term wrinkle injections may specifically include facial expression disorder, nerve paralysis, eyelid muscle paralysis, and systemic symptoms. 1. Facial expression disorder: Early stage of wrinkle injection may cause facial expression disorder, such as stiff smile, eyebrows can not be lifted normally, and so on. 2. Nerve paralysis: Improperly injected parts or levels of wrinkle injections may lead to nerve paralysis, such as involuntary drooling. 3. Eyelid muscle paralysis: if the wrinkle injection is too close to the eyes, it is easy to paralyze the orbicularis oculi muscle and levator palpebralis muscle. 4. Systemic symptoms: wrinkle injections have certain side effects, wrinkle injection overdose may appear systemic symptoms, such as generalized weakness, fever, loss of appetite, etc., and in severe cases, there will be respiratory difficulties, dysphagia and other symptoms. Note: The active ingredient of wrinkle injections is botulinum toxin, which is a controlled poisonous and narcotic drug in clinical practice. If the wrinkle injection is not formal, it may cause some adverse consequences, it is recommended to go to a professional medical institution for injection, which is safer and more reliable, and the probability of side effects is lower.