Prolonged use of sacubitril valsartan sodium tablets may lead to angioedema, renal impairment, hypotension, hyperkalemia and other side effects. 1. Angioedema: Sacubitril valsartan sodium tablets is a compound antihypertensive drug composed of brain curcuminoid peptidase inhibitor sacubitril and angiotensin receptor antagonist valsartan. It can be used in hypertensive patients with chronic heart failure with reduced ejection fraction. Long-term use may lead to angioedema, manifesting edema of the tongue, throat and other parts of the body or even life-threatening. 2. Renal impairment: Sacubitril valsartan sodium tablets, when metabolized by the kidneys, can block the renin-angiotensin and aldosterone system, which may lead to renal impairment with oliguria, progressive azotemia and other manifestations. 3. Hypotension: Sacubitril valsartan sodium tablets, as a combination of two antihypertensive drugs, may lead to the occurrence of hypotension. 4. Hyperkalemia: Sacubitril valsartan sodium tablets may also affect the excretion of blood potassium and hyperkalemia. Sacubitril valsartan sodium tablets may also have side effects such as hepatic impairment when taken for a long period of time, so it is forbidden for patients with allergy to the drug, angioedema, severe hepatic and renal impairment, hyperkalemia and so on. Self-medication is not recommended, it is recommended to take medication under the guidance of a doctor for treatment.