There are many reasons for toe pain while running, which may be caused by certain physiological reasons, such as over-exercise, foot trauma, etc. It is also a symptom of certain diseases, mainly nail groove inflammation and gout. 1. Physiological reasons: After a lot of exercise, excessive pressure on the foot may lead to strain on the joints or ligaments of the toes, thus causing pain in the toes when running. When foot trauma such as abrasions, sprains, etc. may lead to soft tissue injuries, swelling and bruising of the feet, and therefore may lead to toe pain when running. 2. Inflammation of the nail: Inflammation of the nail may occur in patients with toenails growing into the tissues on both sides of the toe, resulting in secondary inflammation and infection of the tissues, the infection spreads to the skin at the end of the finger, resulting in swelling and tingling of the finger, and pain in the toes when running and other sports. 3. Gout: gout patients with uric acid in the body formed crystals, glass fragment-like stones will rub and irritate the joints, resulting in inflammatory changes in the joint cavity, may radiate to the toes resulting in swelling and pain in the big toes, if the gout acute attack while running will lead to toe pain. In addition to the above mentioned diseases, rheumatoid arthritis, osteoarthritis and other diseases will also have symptoms of toe pain when running. When patients have toe pain when running, they should consult a doctor in time for corresponding treatment after excluding physiological factors.