Large areas of hand peeling may be due to exfoliative keratolysis, herpes sweat, tinea cruris and other factors. 1. exfoliative keratolysis: the etiology is unknown, may be related to genetic, emotional, sweating and other factors, to the palm and metatarsal part of the superficial exfoliation as the main manifestation of the white spots, and spread to the surrounding area, the formation of blister film, can be torn off as a thin paper-like scales, accompanied by hyperhidrosis, the severity of the fingers can be chapped, pain and other symptoms. 2. Sweat herpes: with the patient’s physique, mental factors, local stimuli and other factors, common in the palms of the hands, soles and other parts of the feet, manifested as small blisters the size of grains of rice, slightly above the surface of the skin, accompanied by peeling, sweating, itching, and other symptoms, usually recurring on a regular basis every year. 3. Ringworm: when the hands are infected by fungi, dry skin, erythema, papules, peeling, blisters, itching and other symptoms may appear, mainly involving the interphalangeal, palm, and in severe cases, it may spread to the back of the hands and wrists. Large areas of hand peeling may also be caused by other factors, it is recommended that patients seek medical attention in order to clarify the cause of the disease, targeted treatment.