Chronic kidney disease itchy skin is related to the deposition of toxins in the skin and subcutaneous tissues, skin and systemic microinflammatory state. 1. Patients with chronic kidney disease have reduced renal function, metabolites and waste products cannot be excreted from the body, and toxins such as guanidine accumulate in the body, which stimulate the skin and cause itching. 2. Skin and generalized microinflammatory state may stimulate itching. Inflammatory indicators such as CRP, tumor necrosis factor, interleukin-2, interleukin-6, etc. may be significantly higher in patients with chronic kidney disease than in those without itching. Patients with chronic kidney disease who have itchy skin are advised to seek timely medical attention, follow the doctor’s instructions for further examination and targeted treatment under the guidance of specialized physicians.