Blood transfusion therapy for acute lymphoblastic leukemia is useful. However, the decision of whether or not to transfuse blood should be made according to the patient’s specific situation. Acute lymphoblastic leukemia is a kind of leukemia. Patients with leukemia have abnormal cell proliferation and normal hematopoiesis is inhibited, inducing problems such as anemia and thrombocytopenia. Patients with severe anemia of acute lymphoblastic leukemia can be transfused concentrated red blood cells to maintain hemoglobin above 80g/L. However, red blood cells should not be transfused immediately when leukocytes are high, and leukocytes should be lowered first. Patients with low platelet counts in acute lymphoblastic leukemia may bleed and can be transfused with single-recipient platelet suspension. It is important to note that blood transfusion can only improve the patient’s symptoms. To treat leukemia, standardized treatment should be carried out under the guidance of a doctor.