Uric acid down to 300μmol / L after taking febuxostat, uric acid rise again may be due to dietary control is not good, taking febuxostat dosage is small, and so on. 1. Dietary control: high uric acid patients taking Febuxostat uric acid rise again, the first need to adjust the lifestyle, prohibit drinking and smoking, reduce the intake of high-purine food, reduce the intake of fructose-rich beverages, a large number of drinking water per day should be more than 2,000 milliliters to promote the excretion of uric acid, but also need to control the patient’s body weight. 2. smaller dose: when taking febuxostat smaller amount of medicine or taking time is shorter, may also appear uric acid rise again. It is recommended that patients seek medical attention in a timely manner to clarify the cause of the disease under the guidance of the doctor targeted treatment, do not use private medication to avoid causing adverse effects.