Typically, quadruple drugs are more effective in treating H. pylori. A quadruple combination is a medication that consists of a combination of a proton pump inhibitor, two antibiotics, and bismuth. H. pylori is a relatively common bacterium that colonizes mainly the stomach. When treating H. pylori with a quadruple combination, one of the proton pump inhibitors raises the pH level in the stomach, which allows the antibiotics to work better as a bactericidal agent. Antibiotics can inhibit the reproduction of H. pylori, while bismuth can protect the gastric mucosa. The effect of treating H. pylori is better when the quadruple combination of drugs is used in a full course of treatment and in full dosage. The above medicines should be used under the guidance of professional physicians, and the use of quadruple drug treatment should follow the advice of professional physicians.