Hepatitis B virus infection in the early stage generally does not cause blood glucose increase, but if there are complications in the late stage, blood glucose increase may occur. In the early stage of hepatitis B virus infection, liver function is usually normal, which will not affect the metabolism of blood glucose, so there is no increase in blood glucose. If hepatitis B virus infection develops further and serious liver function damage or cirrhosis occurs, it may be related to insulin resistance and hyperinsulinemia caused by liver damage, which may lead to hepatogenous diabetes mellitus. Patients with hepatitis B who develop elevated blood glucose are advised to go to the hospital for evaluation of their condition under the guidance of a specialist and treatment with additional hypoglycemic drugs such as gliclazide and acarbose.