Hepatitis B 2 weak positive and 5 positive means that the patient has been infected with the hepatitis B virus and needs to be vaccinated if the protective antibodies are insufficient. Hepatitis B 5 tests, the fifth item is positive, combined with the second item is weakly positive, it means that the patient has been infected with hepatitis B virus, but the disease has been cured, if the titer of hepatitis B protective antibody produced is insufficient, so the preventive effect is not strong, this situation needs to consider the choice of supplemental hepatitis B vaccine according to the titer. If the antibody titer is less than 10mIU/ml, the patient needs to be re-vaccinated with hepatitis B vaccine; if the antibody titer is higher than 10mIU/ml and less than 100mIU/ml, only a booster shot of hepatitis B vaccine is needed. In addition, hepatitis B vaccination, there are certain contraindications, it is recommended that before vaccination need to consult a specialist.