At the age of 48, the absence of menstruation for 3 months may be a normal manifestation of perimenopause, or it may be caused by pregnancy, or it may be caused by the use of certain medications, the causes are different, and the methods of treatment are different. 1. Physiological factors: 48-year-old women are at the age of perimenopause, so the symptoms of women at this age who have not had a period for three months may be normal, and there is no need to worry too much. 2. Pregnancy: If a 48-year-old woman is not yet menopausal and has conceived a pregnancy, she may also have no menstrual period for three months, which requires timely obstetric examination at the hospital and no special treatment. 3. Drugs: If the patient uses long-acting contraceptives such as medroxyprogesterone acetate, or uses prednisone, chlorpromazine and other drugs, the body’s hormone levels are disturbed, which can lead to amenorrhea, and this situation can be improved after stopping the drug. After eliminating physiological factors, if the symptoms of a 48-year-old woman who has not had her period for three months continue unabated, it is recommended that she consult a doctor in a timely manner to identify the cause and ask the doctor to deal with it.