Long-term acid reflux can cause gastric ulcers, reflux esophagitis, duodenal ulcers, chronic gastritis, and cancer. 1. Gastric ulcer: the excess of gastric acid will lead to corrosion of mucous membrane, resulting in peptic ulcer or even perforation. 2. Reflux esophagitis: long-term acid reflux can easily lead to reflux of gastric contents, which can easily lead to reflux esophagitis. 3. Duodenal ulcer: excessive gastric acid corrosive effect, resulting in gastric mucosal rupture, untimely treatment will appear acid reflux, hiccups, duodenal ulcer. 4. Chronic gastritis: excessive stomach acid, long-term direct mucous membrane of the stomach to form chronic gastritis. 5. Cancer: If acid reflux is not corrected for a long time, it will cause atrophy of gastric mucosa and formation of ulcer, and gastric cancer will appear in the long term. Long-term acid reflux, it is recommended to go to the hospital in time, improve the relevant examination under the guidance of the doctor to make a clear diagnosis, and need to standardize the treatment, so as not to delay the condition.