Proper care during chemotherapy for children with leukemia should pay attention to preventing infection, preventing bleeding, strengthening supervision, maintaining nutrition and so on. 1. Prevention of infection: children with leukemia may have granulocytopenia or lack of granulocytes and low resistance during chemotherapy, so they should be actively prevented from infection, and it is recommended to live in laminar flow wards or sterilized isolation wards to keep the environment clean, low-bacteria and ventilated, and prohibit visiting when necessary. 2. Prevent bleeding: during chemotherapy, children with leukemia may have normal bone marrow hematopoietic function inhibition, which is more likely to lead to bleeding tendency in all parts of the body, care should be taken to prevent bumps and scratches. 3. Strengthen monitoring: during chemotherapy, children’s indicators, such as body temperature, heart rate, respiration, etc., should be closely monitored, and if there is any abnormality, the physician should be informed immediately, and symptomatic treatment should be carried out in time. 4. Maintain nutrition: leukemia is a serious consumptive disease, especially chemotherapy can cause children’s digestive mucositis and dysfunction, dietary care should pay attention to supplemental nutrition, give high protein, high calorie, easy to digest food, maintain water and electrolyte balance, and supplement nutrition through vein when necessary. Children with leukemia should also develop healthy habits in their daily life, which will help them recover.