Hepatitis B surface antigen of more than 3,000 serious need to be combined with hepatitis B virus DNA, liver function, clinical symptoms, liver ultrasound, alpha-fetoprotein and other comprehensive assessment. Hepatitis B surface antigen more than 3,000, itself this value is moderately elevated, if the liver function, liver ultrasound, alpha-fetoprotein are normal, there is no relevant clinical symptoms, there is no obvious tendency of liver fibers, this is not serious, belongs to the virus carriers, regular review of the relevant indicators can be. If the surface antigen of hepatitis B is more than 3,000 and the number of DNA of the virus is obviously increased, and there are abnormalities of liver function, and the ultrasound of the liver suggests that the inflammation of the liver is obvious, this is a more serious situation, and it is necessary to carry out antiviral treatment, such as entecavir. If the ultrasound suggests cirrhosis, liver function is also significantly impaired, liver hardness suggests cirrhosis, this condition is more serious, suggesting that cirrhosis has already occurred, and relevant antifibrotic treatment is needed. If there is an increase in alpha-fetoprotein, liver ultrasound suggests that the performance of liver mass, this need to consider the possibility of combined liver cancer, this condition is also very serious, need oncology consultation. Therefore, it is necessary to analyze the specific situation. Specific medication is recommended to be used under the guidance of a doctor.