Hepatitis C does not cause skin allergies. Hepatitis C is a contagious disease, related to the infection of hepatitis C virus, which is mainly manifested in the clinic as generalized weakness and loss of appetite, and some patients may be accompanied by abdominal distension, nausea, and pain in the right upper abdomen and other symptoms, but it does not cause skin allergic reaction. Chronic hepatitis C patients with severe hepatic impairment may affect the secretion and excretion of bile, resulting in cholestasis, due to the deposition of bile acid salts in the body, the sensory nerve endings of the skin caused by the stimulation of itching discomfort, which in the treatment of this case is mainly given to antiviral, hepatoprotective, hepatoprotective, and cholagogue-based, such as entecavir, hepatoprotective tablets, compound licorice glycoside tablets, and so on. Hepatitis C patients may experience an allergic reaction, also known as pharmacologic dermatitis, during medication administration, but it is not related to the hepatitis C disease itself. Skin allergy is a kind of allergic reaction, related to the skin contact with some kind of sensitizer, which is mainly manifested as macular rash, papule or maculopapular rash, accompanied by itching of different degrees. In the treatment, we should remove the allergens firstly, and then give some antiallergic drugs, such as loratadine tablets, ibrastine tablets, and so on. Since there is no direct connection between skin allergy and hepatitis C, so when hepatitis C patients have skin allergy, they must consult the doctor in time and exclude the causes of allergy.