Swelling of the face after taking hormones for connective tissue disease is one of the common adverse reactions caused by hormones, mostly due to fat redistribution. Connective tissue disease is a group of autoimmune diseases, lesions can involve a number of systems throughout the body and a number of important organs, including systemic lupus erythematosus, rheumatoid arthritis, etc. Glucocorticosteroids, as a kind of therapeutic drug for autoimmune diseases, have a better effect on a number of connective tissue disease groups, such as prednisone, dexamethasone and so on. After taking hormones, there will be a variety of adverse reactions, there may be elevated blood pressure, elevated blood sugar, osteoporosis and other side effects, including facial swelling is also one of the adverse reactions, mostly related to the redistribution of fat after taking hormones, and subsequently produce a full-moon face, buffalo back, etc., resulting in facial swelling. Swelling of the face after taking hormones is generally only a temporary phenomenon, as the condition stabilizes, the amount of hormones will be gradually reduced, and the swelling of the face will be gradually relieved. Connective tissue disease patients are advised to go to the rheumatology and immunology departments of regular hospitals for detailed consultation and standardized treatment according to the doctor’s instructions.