A high total prostate PSA can be reviewed once for a PSA test, and further refinements such as ultrasound, MRI, and prostate puncture can also be done. PSA is a prostate-specific antigen, a protease secreted by prostate cells. When prostate cancer is present, the cancer cells destroy the surrounding normal tissues, causing PSA to enter the bloodstream and the PSA value to appear elevated. However, patients with prostatitis, prostate hyperplasia, and rectal examination may also experience short-term elevation of PSA. In the case of benign prostate disease, PSA can usually drop back to normal in about 4 weeks. If the PSA is elevated in a single blood test, you can watch and wait, and then review a PSA test in 4 weeks. If the PSA value is still high, it is recommended to further improve the transrectal ultrasound, prostate MRI and other tests, and if necessary, prostate puncture biopsy can also be performed to rule out the possibility of prostate cancer. Elevated total PSA of the prostate is recommended to actively seek medical attention, and management and treatment under the guidance of a physician.